Sony Alpha A7R IV Samples

The extremely high-resolution of the Sony Alpha A7R IV is the first time a full-frame camera surpasses a resolution offered by Medium Format modesl. Although technology allows Medium Format cameras to offer even higher resolution now, the A7R IV naturally draws comparisons between the two formats. Below are 100% crops taken from the A7R IV at every ISO next to a similar crops from the Fujifilm GFX-50S reviewed here
Fujifilm GFX 50S.

The Medium Format Fujfilm GFX-50S sports a 50 megapixels 44x33mm CMOS sensor, compared to the 61 megapixels 36x24mm one in the Sony Alpha A7R IV. The larger sensor area generally results in higher signal-to-noise ration which allows for lower image-noise and greater dynamic-range. This also means that the GFX-50S has significanly larger pixels than the A7R IV. In fact, only Medium Format cameras currently capture 16-bit per pixel-component which allows a full 2 stops more shadown details compared to the 14-bit output from Full-Frame cameras.

Sony A7R IV	Fujifilm GFX-50S
ISO 50	ISO 50
ISO 100	ISO 100
ISO 200	ISO 200
ISO 400	ISO 400
ISO 800	ISO 800
ISO 1600	ISO 1600
ISO 3200	ISO 3200
ISO 6400	ISO 6400
ISO 12800	ISO 12800
ISO 25600	ISO 25600
ISO 51200	ISO 51200
ISO 102400	ISO 102400

Looking through all the above crops, it is clear that Medium Format offers a significant advantage when it comes to image-quality. Photos from the Fujifilm GFX-50S show 2-stop better noise and roughly 1½-stop more dynamic-range. The trade off is that the larger sensor for a bulkier camera which requires larger and heavier lenses. Keep in mind that these are huge images and there differences might not be apparent when printed.